Grace J. Wang, Andrew J. Layne, Emile R. Mohler, Julia T. Davis, Seema S. Sonnad, Ronald M. Fairman
Vascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA.
OBJECTIVES: Arterial intima thickness (IMT) of the carotid artery has been established as a surrogate marker of atherosclerosis. The role of femoral IMT remains incompletely defined. This study was undertaken to better define the potential relationship between patient demographics, co-morbidities and femoral IMT.
METHODS: One-hundred sixty patients (89 male, 71 female) between the ages of 18 and 50 were enrolled and demographic data was obtained by chart review. Images of the common femoral artery were obtained using B-mode ultrasonography gated to the R-wave of the electrocardiograph. Automated edge detection software was used to measure femoral IMT and vessel diameter and these measurements were used to derive the IMT cross-sectional area (CSA). Triplicate measurements of each femoral artery were made and averaged. T-tests and multivariate analysis were performed and significance was indicated by a p-value<0.05.
RESULTS: The mean femoral IMT measurements for men and women were 0.514+0.011 mm and 0.465+0.005 mm, respectively. Univariate analysis found significant differences in IMT for gender, age, presence of diabetes, hypercholesterolemia and hypertension. Univariate analysis found significant differences in CSA for gender, age, race, BMI, and presence of CAD, CRI, hypercholesterolemia and hypertension. When significant variables were included in a multivariate regression, age and gender (p<0.001) remained significant predictors of IMT and age, gender and BMI (p<0.001) remained significant predictors of CSA.
CONCLUSIONS: In this subset of patients, multivariate analysis revealed a thicker IMT in males and in patients >35 years of age. Greater IMT CSA was associated with male gender, age >35 and BMI >30.These findings have ramifications for the future study of femoral IMT as it relates to atherosclerosis and vessel remodeling.
AUTHOR DISCLOSURES: J. T. Davis, Nothing to disclose; R. M. Fairman, Nothing to disclose; A. J. Layne, Nothing to disclose; E. R. Mohler, Nothing to disclose; S. S. Sonnad, Nothing to disclose; G. J. Wang, Nothing to disclose.
Posted April 2012