Vascular Web Logo

SVS  SVS Foundation

 Understanding Gender Differences in Disease Patterns for Aneurysms is Critical

New knowledge may help develop new translational approaches for prevention and treatment

June 17, 2011   Contact: Sue Crosson-Knutson    312-334-2311

CHICAGO - At the 65th Vascular Annual Meeting of the Society for Vascular Surgery®, Gilbert R. Upchurch, Jr., MD from the division of thoracic and cardiovascular surgery at University of Virginia Health System in Charlottesville, spoke about gender differences in abdominal aortic aneurysms (AAA’s).
“Abdominal aortic aneurysms comprise the 10th leading cause of death in Caucasian males 65-74 years of age and accounted for nearly 16,000 deaths in the year 2000,” said Dr Upchurch. “Therefore, understanding the pathophysiology of AAA’s is an important

Dr. Upchurch reported that even though male gender is a well-established risk factor for the development of an AAA with a 4:1 male to female ratio however the reason for this gender disparity is unknown.         

“Clinically, multiple risk factors are associated with the development of AAA’s, including increasing age, positive smoking history and hypertension,” said Dr. Upchurch. “The pathogenesis of AAA’s formation is complex and multi-factorial. Histologically, AAA’s are characterized by early chemokine driven leukocyte infiltration into the aortic wall. Subsequent destruction of elastin and collagen in the media and adventitia ensues due to excessive local production of matrix degrading enzymes, and is accompanied by smooth muscle cell loss and thinning of the aortic wall.”

Presently there are no medical therapies available to treat patients with aortic aneurysms, using only the crude measurement of aortic diameter as a threshold for which patients must undergo life-threatening and costly surgery, added Dr. Upchurch. “Defining the early mechanisms underlying gender-related differences in AAA formation are critical, as understanding differences in disease patterns based on gender may allow us to develop new translational approaches to the prevention and treatment of patients with aortic aneurysms.”
# # #
About the Society for Vascular Surgery
The Society for Vascular Surgery® (SVS) is a not-for-profit professional medical society, composed primarily of vascular surgeons, that seeks to advance excellence and innovation in vascular health through education, advocacy, research, and public awareness. SVS is the national advocate for 3,370 specialty-trained vascular surgeons and other medical professionals who are dedicated to the prevention and cure of vascular disease. Visit its Web site at® and follow SVS on Twitter by searching for VascularHealth or at


Contact Us

Society for Vascular Surgery
633 North Saint Clair Street, 22nd Floor | Chicago, IL 60611
Phone: 312-334-2300 | 800-258-7188
Fax: 312-334-2320

Follow Us


VascularWeb® is the prime source for all vascular health and disease information, and is presented by the Society for Vascular Surgery®. Its members are vascular surgeons, specialists, and vascular health professionals who are specialty-trained in all treatments for vascular disease including medical management, non-invasive procedures, and surgery.